公共卫生研究摘要 (2026-01-26)
共收录 61 篇研究文章
1. Rethinking the Role of HIV/AIDS Memories in Gay Men's Experiences of COVID-19 Fear: The Centrality of Social and Ethnic Inequalities.
期刊: Sociology of health & illness 发表日期: 2026-Feb 链接: PubMed
摘要
This paper examines how gay men in the UK experienced fear during the COVID-19 pandemic, and how these experiences were shaped by memories of HIV/AIDS, ethnicity, socio-economic position and access to social support. Although much scholarship assumes that HIV casts a long shadow over gay men’s responses to subsequent health crises, we explore to what extent HIV memories actually structured COVID-19 fear. Drawing on 45 semi-structured interviews with gay men of diverse ages, ethnic backgrounds and HIV statuses, we identify three overlapping forms of COVID-19 fear: fear of contagion, fear of infecting others, and fear about societal futures. Although some participants explicitly drew parallels with the AIDS crisis, most described HIV and COVID-19 as too different in transmission, temporality and social meaning for HIV memories to be central to their experiences of fear. Instead, COVID-19 fear was most powerfully patterned by socio-economic precarity and the presence or absence of social support networks. These forms of vulnerability were disproportionately reported by ethnic minority men. Our findings challenge assumptions about the primacy of HIV memory in shaping gay men’s pandemic experiences and re-centre contemporary inequalities as key determinants of COVID-19 fear.
2. Corneal stromal stem cell-derived extracellular vesicles inhibit corneal neovascularization.
期刊: Indian journal of ophthalmology 发表日期: 2026-Feb-01 链接: PubMed
摘要
Corneal neovascularization (CNV) threatens corneal transparency and is a leading cause of vision loss. This study evaluates the anti-angiogenic effects of extracellular vesicles (EVs) derived from human corneal stromal stem cells (CSSCs). Cultured human umbilical vein endothelial cells (HUVECs) were treated with CSSC-EVs to examine the influence on cell growth and modulation of angiogenesis using xCELLigence and tube formation assays. In vivo, a mouse model of CNV was induced by silver nitrate (AgNO₃) cauterization, and the injured corneas were treated with CSSC-EV eye drops twice daily for four days. On day 10, new vessel formation on mouse corneas was graded, and the expression of angiogenic markers was assessed using immunostaining and qPCR. Results were analyzed using one-way ANOVA. HUVEC cultures treated with CSSC-EVs showed reduced growth with a significant increase in cell doubling time. On Geltrex-coated culture surface, HUVECs incubated with CSSC-EVs generated reduced numbers of vascular tube structures, with significantly reduced junctions and nodes. In vivo, CNV developed in AgNO₃-cauterized mouse corneas by day 10 post-injury. Eye drop treatment with CSSC-EVs attenuated the formation of new vessels expressing vascular marker CD31 and lymphatic marker LYVE1. Compared to injured controls treated with phosphate-buffered saline (PBS) eye drops, the expression of angiogenic markers, including ANGPT1 and 2, CD31, VEGFA, VEGFR1, and R2, was significantly downregulated in EV-treated corneas (P < 0.05). The anti-angiogenic effect of CSSC-EVs demonstrated their potential to inhibit CNV. Overall, the topical application of CSSC-EVs was safe and effective for addressing CNV-related pathologies.
3. Steam sterilization: Review of autoclaves, validation, instrument packing, and sterility failures.
期刊: Indian journal of ophthalmology 发表日期: 2026-Feb-01 链接: PubMed
摘要
Surgical care for the disease is required in a significant number of people worldwide. In India, approximately 4% of the population needs surgical care. In ophthalmology, lens-based surgeries account for a significant contribution to the list. In this massive volume of surgeries, a proper sterilization process is vital for the successful outcome of these surgeries. Healthcare professionals must have an in-depth understanding of the sterilization process, which helps reduce complications and prevent terminal events.
4. Social connection and living with severe chronic obstructive pulmonary disease: A qualitative analysis.
期刊: Journal of health psychology 发表日期: 2026-Jan-25 链接: PubMed
摘要
People with chronic obstructive pulmonary disease (COPD) face increased risk of social isolation and loneliness. However, social dimensions are frequently overlooked in respiratory care. We aimed to explore the role of social connection in living with COPD, including influences on health and function. We conducted a reflexive thematic analysis of semi-structured interviews with 19 people with COPD (median age 78 years [range 58-88]; 14 with severe airflow obstruction). Three themes were identified: social connection supports COPD self-management, the “triple threat” of COPD to social connection, and the inseparable nature of social health. Participants described how worsening symptoms, particularly breathlessness, contribute to disconnection through physical restrictions, psychological reactions, and societal unawareness, with negative impacts on self-management and wider physical and psychological health. We conclude that social connections become increasingly valuable, yet increasingly difficult to maintain, as COPD progresses. Supporting individuals to maintain connections within a biopsychosocial approach may unlock wider health benefits.
5. The cervical cancer divide: State variation in incidence, mortality, and progress toward elimination in the US.
期刊: JNCI cancer spectrum 发表日期: 2026-Jan-25 链接: PubMed
摘要
Cervical cancer elimination (<4 cases per 100,000) is a critical cancer prevention goal in the United States. Implementation of health policies and allocation of health resources occur at regional and state levels; therefore, understanding region- and state-specific cervical cancer incidence, mortality, and progress towards elimination-and remaining gaps-is essential. We estimated hysterectomy-corrected cervical cancer incidence, mortality, and progress toward elimination across all 50 states, the District of Columbia, and Puerto Rico. In 2021, Massachusetts was the only state nearing (4.3 per 100,000) the elimination threshold. Southeastern and Southwestern states were farthest, with the highest incidence rates in Mississippi (14.8), Louisiana (14.2), and Oklahoma (13.8). The mortality rate ranged from 6.8 (Alabama) to 1.4 (Wisconsin). In most states, cervical cancer incidence and mortality did not change from 2007-2011 to 2017-2021. Identifying and addressing regional- and state-level barriers impeding progress will be key to achieving cervical cancer elimination.
6. Effects of Environmental Factors on Spore Germination of Valsa mali.
期刊: Plant disease 发表日期: 2026-Jan-25 链接: PubMed
摘要
Apple Valsa canker, caused by Valsa mali, is a serious disease affecting apple trees. Saprophytic colonization is a crucial stage in the infection process, with spore germination being a prerequisite for this phase. The effects of nutrients, temperature, moisture, pH, and light on the germination of both conidia and ascospores of V. mali were investigated under controlled environmental conditions. The results showed that the germination of V. mali spores requires supplementary nutrients, and compound nutrients are more conducive to spore germination. In distilled water, neither conidia nor ascospores germinated, resulting in a germination rate of 0%. In a sugar solution, the maximum germination rate remained below 75%. However, germination rates reached 100% in media supplemented with bark extract, fruit extract, or potato dextrose (PD) culture medium. The temperature range for conidial germination was 3.1-34.8°C, with an optimum of 25.6°C. Conidial germination required a duration of wetness or relative humidity exceeding 97% to be sustained for at least 7.6 hours. The suitable pH range for conidial germination was 4-8. In contrast, ascospore germination occurred over a broader temperature range of 0.6-41.7°C, with an optimum of 25.6°C. Ascospore germination required a relative humidity above 90% for at least 6.8 hours and was supported by a wider pH range of 4-10. Light significantly inhibited conidial germination but had no observable effect on ascospore germination. These results can be used to construct a prediction model that estimates the amount and timing of V. mali colonization on branch surfaces based on environmental and nutritional conditions. This prediction model can then inform the timing and methods for implementing apple Valsa canker control programs more effectively.
7. Care Coordination and Communication for Native American Patients with Cancer.
期刊: The oncologist 发表日期: 2026-Jan-25 链接: PubMed
摘要
8. Preoperative plasma glial fibrillary acidic protein and postoperative delirium in older adults.
期刊: The journals of gerontology. Series A, Biological sciences and medical sciences 发表日期: 2026-Jan-25 链接: PubMed
摘要
Delirium is a common complication of hospitalization with poor outcomes, but its underlying pathophysiology is poorly understood. We investigated the association of preoperative glial fibrillary acidic protein (GFAP), a biomarker of reactive astrocytosis, with delirium incidence and severity. Data were obtained from the ongoing prospective Successful Aging after Elective Surgery (SAGES) study. GFAP was measured in preoperative plasma (n = 529). Post-operative delirium incidence and severity were measured using the Confusion Assessment Method (CAM) and CAM-S (0-19, 19 worst), respectively. A multivariable generalized linear model (GLM) with log link and binary or Poisson error distribution was used to estimate the relative risk of delirium by GFAP quartile scale, and GLM with identity link was used to examine the association of preoperative GFAP and delirium severity. Overall mean preoperative GFAP value was 289.6 ± 153.3 pg/ml; mean value by quartile (Q) was 148.1 ± 28.6 pg/ml for Q1, 220.5 ± 19.8 pg/ml for Q2, 298.2 ± 28.4 pg/ml for Q3, and 503.4 ± 128.3 pg/ml for Q4. Delirium incidence by GFAP level was 16% in Q1, 24% in Q2, 25% in Q3, and 28% in Q4 (Cochran Trend test P-value = 0.031; adjusted P-value = 0.205). Higher GFAP levels (4th vs. 1st quartile) were associated with greater risk of incident delirium (adjusted relative risk 1.70, 95% confidence interval (CI): 1.01-2.86) and greater delirium severity (adjusted mean difference 0.86, 95% CI: 0.004-1.71). High preoperative plasma GFAP was associated with increased delirium incidence and severity, suggesting GFAP may serve as a risk marker for delirium. Brain vulnerability in the setting of astrocytosis may contribute to delirium pathophysiology.
9. Effect of surgical resection on isolated pleural dissemination in patients with stage IV (M1a) non-small cell lung cancer: Analysis from a cohort-based registry and a population-based database.
期刊: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 发表日期: 2026-Jan-25 链接: PubMed
摘要
Non-small cell lung cancer (NSCLC) with pleural dissemination is categorized as stage IV (M1a) and traditionally deemed a contraindication for surgical intervention. This study aimed to explore the potential role of surgery in NSCLC patients with isolated pleural dissemination. Patients who either underwent primary tumour resection (PTR) or received only pleural nodules biopsy were included for analysis from Western China Lung Cancer (WCLC) database (2005-2021) and Surveillance, Epidemiology, and End Results (SEER) database (2010-2015). Survival curves were generated using the Kaplan-Meier method, with significance assessed by the log-rank test. A total of 289 patients (261 PTR and 28 biopsy only) from the WCLC cohort and 2,232 patients (278 PTR and 1,954 biopsy only) from the SEER cohort were identified for analysis. In both cohorts, patients who underwent PTR showed significantly better outcomes compared to those who received only pleural nodules biopsy, with the 5-year survival rates of 28.3% versus 5.0% in the WCLC cohort (P < 0.0001) and 30.5% versus 7.4% in the SEER cohort (P < 0.0001). Subgroup analysis indicated that PTR significantly improved survival in patients without malignant pleural effusion, regardless of tumour size and T stage. Furthermore, anatomic lobectomy with systematic lymph node dissection was associated with better overall survival than partial resection or lobectomy plus lymph node sampling (P = 0.008). NSCLC patients with isolated pleural dissemination may represent an M1a subgroup in whom primary tumour resection is associated with longer survival, particularly in the absence of malignant pleural effusion.
10. Leveraging Community Drug Outlets for Vaccination Delivery in Tanzania: A Qualitative Study to Inform Future Implementation.
期刊: The International journal of health planning and management 发表日期: 2026-Jan-25 链接: PubMed
摘要
A prior pre-implementation survey in Tanzania identified moderate feasibility and low acceptability of integrating vaccination services into community drug outlets (CDOs). The qualitative review was conducted to gain deeper insight into the factors influencing the feasibility and acceptability of integrating vaccination services into CDOs, such as community pharmacies and Accredited Drug Dispensing Outlets (ADDOs). A descriptive qualitative design was employed as part of an explanatory sequential mixed-methods approach. Interviews were conducted with purposively sampled stakeholders, guided by findings from the prior survey. Interviews were audio-recorded and transcribed verbatim, then thematically analysed using implementation science frameworks, with coding supported by Nvivo software. A total of 17 qualitative interviews were conducted with 46 participants across Dar es Salaam, Pwani, and Dodoma, including community members, health providers, regulators, and supply chain personnel. Six themes emerged: feasibility, acceptability, training, policy, infrastructure, and economics. Community pharmacies were viewed as more feasible and better equipped than ADDOs, which face more severe challenges related to limited space, inadequate cold chain capacity, and insufficient staffing. Acceptability was higher for pharmacies, though both settings (pharmacy and ADDO) require policy, training, and infrastructure improvements. Community pharmacies show greater readiness than ADDOs for vaccine delivery due to better infrastructure, professional staffing, and regulatory alignment. However, both face challenges requiring policy reform, training, and support systems. Future studies should assess operational readiness and develop national standards to guide safe, equitable, and sustainable pharmacy-based immunisation services.
11. Physical activity and the aging brain: A narrative review.
期刊: Journal of health psychology 发表日期: 2026-Jan-25 链接: PubMed
摘要
With a global annual cumulative incidence of depression at 4.5% in community-dwelling older adults, understanding non-pharmacological interventions is essential. This narrative review explores the neuroprotective mechanisms of physical activity (PA) on brain function and mental health in individuals aged 60 and older. We conducted a search across multiple databases (MEDLINE, PsycINFO, EMBASE) using keywords related to aging, cognition, and physical activity. Our analysis of relevant studies shows that PA benefits the brain through several pathways. Early findings focused on improved cerebral blood flow and glucose utilization. More recent evidence highlights that PA increases neurotrophic factors like BDNF and IGF-1, enhances mood-regulating neurotransmitters, and promotes structural adaptations in key brain regions. These findings suggest that PA is a cost-effective, multi-domain intervention. This review provides healthcare professionals with actionable evidence to incorporate PA into clinical practice for older adults.
12. p16Ink4a-Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway.
期刊: Advanced science (Weinheim, Baden-Wurttemberg, Germany) 发表日期: 2026-Jan-25 链接: PubMed
摘要
As organs undergo the process of aging, they exhibit signs of progressive fibrosis, a hallmark of aging that is observed in various organs, including the liver, kidneys, and lungs. Liver fibrosis is a particularly deleterious outcome of the healing processes that occur during the repair of chronic liver injury. It is widely accepted that the majority of these injuries are initially triggered by hepatocytes. Indeed, elderly patients have been shown to be more prone to developing liver fibrosis following hepatic injury. However, the mechanisms by which aging promotes fibrotic processes remain to be elucidated. The preceding observation, indicating a robust correlation between the severity of fibrosis in human cirrhotic patients and the population of hepatocytes expressing elevated levels of p16Ink4a (p16h), proposes that p16h hepatocytes might serve as initiators of fibrogenic processes in response to liver injury. In this study, we employed a CCl4-induced hepatitis model to promote a fibrogenic process and observed the accumulation of p16h hepatocytes in zone 3. These p16h cells manifest numerous senescent characteristics, and their accumulation has been strongly correlated with the severity of liver fibrosis. Selective elimination of p16h hepatocytes has been shown to ameliorate CCl4-induced liver fibrosis, presumably through the suppression of hepatic stellate cell activation. Single-cell transcriptomic analysis revealed that murine and human hepatocytes up-regulated Ctf1 or Lif, the ligands of the LIFR signaling pathway. The administration of LIFR ligands has been demonstrated to enhance the phosphorylation of STAT3, and the LIFR inhibitor rescued the fibrogenic phenotype in hepatic stellate cells induced by secreted factors from senescent hepatocytes. This finding offers potential therapeutic insights for the management of liver fibrosis.
13. CCTA as a Screening Tool (Invited Commentary).
期刊: The British journal of radiology 发表日期: 2026-Jan-25 链接: PubMed
摘要
Coronary computed tomography angiography (CCTA) has evolved into a key non-invasive tool for evaluating coronary artery disease, offering high sensitivity, detailed anatomical visualization, and strong prognostic value. Current Society of Cardiovascular Computed Tomography guidelines recommend CCTA as a first-line test for symptomatic patients, while limiting its use in asymptomatic individuals to select high-risk cases. Advantages in a screening context include early detection of subclinical atherosclerosis, prognostic assessment through high-risk plaque features, and facilitation of personalized preventive strategies. However, widespread screening faces challenges: procedural complexity, contrast and radiation exposure, psychological impact, and economic cost. Emerging integration of artificial intelligence promises to enhance efficiency, automate plaque quantification, and enable individualized risk prediction, potentially improving cost-effectiveness and clinical adoption. Future validation through randomized controlled trials and real-world data is needed to confirm the impact of CCTA-based screening on cardiovascular event reduction, healthcare resource use, and patient quality of life.
14. CYP1B1 Modulates Stress and Repair Pathways in Airway Cells Challenged by Wood Smoke Particles.
期刊: Toxicological sciences : an official journal of the Society of Toxicology 发表日期: 2026-Jan-25 链接: PubMed
摘要
Environmental pollution negatively impacts respiratory health by damaging and reprogramming airway epithelial cells (AECs). CYP1B1 is one of the most highly induced genes in AECs exposed to combustion-derived air pollutants such as wood smoke particulate matter (WSPM) and plays dual roles in generating toxic reactive intermediates and in the detoxification of xenobiotics of diverse nature. However, the significance of CYP1B1 induction by AECs challenged with pollutants remains unclear. A comparison of BEAS-2B and CYP1B1-overexpressing BEAS-2B cells revealed that CYP1B1 overexpression reduced acute cytotoxicity and enhanced proliferation and migration following WSPM-induced injury in vitro. Conversely, inhibition of CYP1B1 in HBEC3-KT cells increased cytotoxicity and decreased proliferation. CYP1B1 inhibition in HBEC3-KT cells exacerbated endoplasmic reticulum stress (ERS), which promotes cell cycle arrest and cytotoxicity, while overexpression of CYP1B1 attenuated ERS. CYP1B1 Inhibition also enhanced the expression of mRNA for the NRF2 target genes NQO1 and HMOX1, and the pro-inflammatory cytokine IL8, whereas CYP1B1 overexpression downregulated mRNA expression for NQO1 and HMOX1. In vivo, Cyp1b1-deficient mice exhibited greater basal lung inflammation, but limited response to WSPM-treatment compared to wild-type mice. However, Cyp1b1-/- derived mouse tracheal epithelial cells (MTEC) treated with WSPM showed a more pronounced inflammatory response, characterized by exacerbated Cxcl1, Cxcl2, and Trpa1 mRNA expression compared to wild-type cells. In conclusion, CYP1B1 mitigates WSPM-induced damage to AECs by squelching ERS, oxidative stress, NRF2, and inflammatory signaling, thereby supporting cellular defense and repair. Additional interactions with CYP1A1 and TRP channels also suggest a broader role in AEC physiology.
15. Review on Nanotoxicology and Nano-Bio Interactions: influencing factors, assessment methods, mechanisms, and applications.
期刊: Environmental toxicology and chemistry 发表日期: 2026-Jan-25 链接: PubMed
摘要
Nanotechnology serves as a nanoscale interface that directly bridges our perception of the macroscopic world with the intricate nanoworld where individual biomolecules reside. This technology has emerged as a luminary in the domains of biology and medicine, paving the way for novel medical research. However, the widespread and indiscriminate use of nanomaterials raises significant concerns regarding environmental, health, and safety issues for the public. Hence, understanding the toxicological properties of nanomaterials in biological interactions becomes pivotal for their safe application. A key challenge in this field lies in the complex and dynamic nature of nano-bio interactions, the strong dependence of toxicity on the physicochemical properties of nanomaterials, and the lack of standardized and predictive toxicity assessment methods capable of supporting reliable risk evaluation and safe-by-design strategies. This review article delves into the potential biological risks and influencing factors contributing to the toxicity of common nanomaterials. Additionally, it explores the mechanisms underlying nano-bio interactions and applications of nanomedicine. The antiviral strategies based on nanomaterials are also introduced, and the possible risks and benefits of nanomaterials in specific nanomedicine applications are described through illustrative examples. Future research should focus on integrating artificial intelligence and advanced models for predictive toxicology, alongside long-term biosafety studies. The goal of this review is to facilitate a deeper understanding of the underlying biological processes between nanomaterials and biological systems. We strive for solving the problem of reducing the threats in the initial stage of nano-products design, ultimately providing theoretical support for better research on nanotoxicology.
16. Developmental toxicity and cardiotoxicity of titanium carbide Ti3C2Tx (MXene) nanosheets in zebrafish embryos.
期刊: Environmental toxicology and chemistry 发表日期: 2026-Jan-25 链接: PubMed
摘要
The two-dimensional nanomaterial MXene Ti3C2Tx is widely used in biomedical and water treatment research. However, the biotoxic effects and mechanisms of Ti3C2Tx in aquatic organisms remain unclear. The present study combined non-targeted metabolomics techniques and traditional toxicological methods to investigate the developmental toxicity of two sheet sizes of Ti3C2Tx-large diameter (Ti3C2Tx-LD) and Ti3C2Tx-small diameter (Ti3C2Tx-SD) to zebrafish embryos and clarify the underlying mechanisms. The results showed that the 96-hr median lethal concentrations (LC50) of Ti3C2Tx-LD and Ti3C2Tx-SD were 35.09 and 50.33 mg/L for zebrafish embryos (96 hr post fertilization), respectively, and the larger sheet size was more toxic. Both Ti3C2Tx-LD and Ti3C2Tx-SD induced concentration-related developmental abnormalities of delayed hatching, excessive reactive oxygen species (ROS) production, pericardial edema, pericardial cell apoptosis and reduced heart rate in zebrafish embryos. Metabolomics revealed that both Ti3C2Tx-LD and Ti3C2Tx-SD caused cardiac developmental toxicity in zebrafish embryos, although via different pathways of action, as Ti3C2Tx-LD mainly disrupted the glycerolipid and glycerophospholipid metabolism pathways, whereas Ti3C2Tx-SD mainly interfered with the arginine biosynthesis pathway. The results of this study highlight that Ti3C2Tx has developmental toxicity and cardiotoxicity to zebrafish embryos and should be fully evaluated for biosafety and environmental risks before mass industrial applications.
17. Applications of nanoparticles in plant disease identification and control for sustainable crop production.
期刊: Discover nano 发表日期: 2026-Jan-25 链接: PubMed
摘要
Nanotechnology is a vast field applicable in various areas of study, including agriculture. Nanoparticles (NPs) can be used in plant disease control in many ways, including as fungicide delivery systems and to enhance cell-to-cell interactions in plants. Their ease of use can be manipulated not only for disease control in crop production but also for the identification of plant diseases. Information on the use of NPs for plant disease control and disease identification was collated. Mechanisms of action of NPs were outlined and discussed. Through these mechanisms, ZnO-NPs reduced Fusarium wilt symptoms in tomatoes by 28.57% and provided 67.99% protection. Ag-NPs promoted a 49.2% reduction of bacterial leaf blight disease in rice caused by Xanthomonas oryzae pv. oryzae. Various techniques involving NPs have been developed for plant disease identification and have shown promise. To ensure the sustainability of applications of NPs and crop production, several knowledge gaps need to be addressed. These include the timeliness of disease identification, the lack of standardised toxicity assessment protocols for NPs, and the paucity of information on NPs-microbiome-plant tri-interactions under field conditions. Furthermore, integration of NPs biosensing with remote sensing or innovative agricultural tools, and the unclear impact of NPs accumulation on soil enzyme activity and nutrient cycling, needs to be addressed. Further study is required to develop a novel technique for real-time identification of plant disease and to accurately identify and quantify the appropriate NPs for specific plant diseases.
18. MGM as a Large-Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts.
期刊: Advanced science (Weinheim, Baden-Wurttemberg, Germany) 发表日期: 2026-Jan-25 链接: PubMed
摘要
Microbial communities are integral to human health, biotechnology, and environmental systems, yet their analysis is hindered by data heterogeneity and batch effects across studies. Traditional supervised methods often fail to capture universal patterns, limiting their utility in diverse contexts. Here, we present the Microbial General Model (MGM), the first large-scale foundation model for microbiome analysis, pretrained on 260,000 samples using transformer-based language modeling. MGM employs self-attention mechanisms and autoregressive pre-training to learn contextualized representations of microbial compositions, enabling robust transfer learning for downstream tasks. Benchmark evaluations demonstrate MGM’s superior performance over conventional methods (average ROC-AUC = 0.99 vs. 0.68-0.97) in microbial community classification, with enhanced generalization across geographic regions. MGM also captures spatial and temporal microbial dynamics, as evidenced by its application to a longitudinal infant cohort, where it delineated delivery mode-specific microbiome trajectories and identified keystone genera such as Bacteroides and Bifidobacterium in vaginal deliveries and Haemophilus in cesarean deliveries. Furthermore, through prompt-guided generation, MGM produced realistic microbial profiles conditioned on disease labels. By integrating self-supervised learning with domain-specific fine-tuning, MGM advances the scalability and precision of microbiome analyses, offering a unified framework for diagnostics, ecological studies, and therapeutic discovery.
19. Exploring the Association between Epigenetic Age and Intensive Care Unit Delirium: A Pilot Feasibility Study.
期刊: The journals of gerontology. Series A, Biological sciences and medical sciences 发表日期: 2026-Jan-25 链接: PubMed
摘要
Epigenetic clocks (EC) measuring epigenetic age (EA) and epigenetic age acceleration (EAA) are biomarkers of biological aging, but their association with intensive care unit (ICU) delirium remains underexplored. This is a pilot study utilizing blood samples from participants enrolled in Pharmacological Management of Delirium (PMD). Serum samples were collected within 48 hours of ICU admission. DNA isolated from serum clots was analyzed in triplicate for DNA methylation (DNAm). EA and EAA were computed for the Horvath, Hannum, PhenoAge, Horvath Skin & Blood, Telomere Length (TL), Best Linear Unbiased Predictor (BLUP), Elastic Network (EN), GrimAge1, GrimAge2, and DunedinPACE ECs from DNAm data. Principal-component clocks were also assessed. Coma, delirium, and delirium severity were assessed twice daily. LOS was assessed using electronic medical records. Spearman correlations were computed for relationships between EA/EAA and delirium outcomes using SAS. A convenience sample of 20 ICU patients with delirium was included. Mean age was 66.7 years (SD = 11.3), 12% were female, and 50% were Black. The median delirium/coma-free days (DCFD) by day 8 were 3 (IQR 0, 6.5). The intra-class correlation coefficients for EA ranged from 0.893 to 0.999, indicating good reliability and minimal variability across the replicates. EN EAA was moderately inversely correlated with mean CAM-ICU-7 scores by day 8 (Spearman r= -0.54, p = 0.01) and discharge (r= -0.48, p = 0.03). No other correlations between other EA/EAAs and delirium, ICU or hospital LOS reached statistical significance. This pilot study demonstrates the feasibility of using ECs from serum clots. Larger studies are needed to assess the relationship between EA/EAA and delirium.
20. Traumatic loss, bereavement, and prolonged grief disorder in times of war: insights from Ukraine.
期刊: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 发表日期: 2026-Jan-24 链接: PubMed
摘要
21. Reply: Persistent Racial Disparities in Lung Cancer Survival and the Overlooked Role of Post-Treatment Care.
期刊: QJM : monthly journal of the Association of Physicians 发表日期: 2026-Jan-24 链接: PubMed
摘要
22. EHealth intervention for quality of life in long-term breast cancer survivors: Randomized controlled trial.
期刊: Journal of the National Cancer Institute 发表日期: 2026-Jan-24 链接: PubMed
摘要
Digital health interventions have shown promise for improving quality of life, especially in the short term after treatment. However, evidence regarding long-term breast cancer survivors (LT-BCSs; disease free >5 years) remains limited. This study aimed to evaluate the effectiveness of an eHealth intervention targeting health promotion and late sequelae management to improve LT-BCSs’ quality of life. In a randomized controlled clinical trial, 201 LT-BCSs (mean 11 years posttreatment) were randomly assigned to an interventio group (n = 102) using the CUMACA-M mobile application with specific health advice and recommendations for LT-BCSs, or a control group (n = 99) receiving usual care. Quality of life was measured with the Quality of Life-Cancer Survivors scale (QOL-CS) at baseline and after 3 months. Analyses followed an intention-to-treat approach using t-tests, nonparametric tests, and effect sizes. At three months, no statistically or clinically significant differences between the groups in the overall quality of life score (QOL-CS) were found (difference of differences = 0.11; 95% CI -0.10 to 0.32; p = .303). In the intervention group, a small intragroup decrease in spiritual well-being was observed -0.25 (-0.49 to -0.02), of uncertain clinical significance; no significant differences between groups were detected. This eHealth intervention did not improve the quality of life of LT-BCSs, suggesting that more personalized, interactive, or professionally supported strategies may be needed. Future research should evaluate the long-term outcomes and effectiveness of hybrid or personalized digital strategies in this population. ClinicalTrials.gov NCT05322460; https://clinicaltrials.gov/study/NCT05322460.
23. Sleep, Metabolites, and Global Cognition: A Mediation Analysis of Plasma Metabolic Profiles in the West China Health and Aging Cohort.
期刊: The journals of gerontology. Series A, Biological sciences and medical sciences 发表日期: 2026-Jan-24 链接: PubMed
摘要
Growing evidence connects sleep disorders with cognitive impairment in older adults, though underlying biological mechanisms remain unclear. We investigated how plasma metabolic profiles mediate the relationship between sleep patterns and global cognition. In a cross-sectional analysis of 3,888 participants aged ≥60 years from the West China Health and Aging Cohort, we analyzed associations between 221 metabolites with both sleep characteristics and cognitive outcomes (assessed via Mini-Mental State Examination), evaluated mediating roles of individual metabolites and composite metabolite scores, and assessed joint associations of genetic susceptibility, sleep patterns, and metabolic profiles with cognitive function. Analyses were adjusted for demographic, lifestyle, comorbidity, and medication factors. We identified 93 metabolites associated with sleep characteristics and 26 linked to cognitive outcomes. Four individual metabolites-ketoleucine, dodecanoic acid, ribonic acid, and ortho-hydroxyphenylacetic acid-mediated 1.67-3.25% of the sleep-cognition associations. Composite metabolite scores-both unrestricted and those restricted to branched-chain amino acid (BCAA) pathways-demonstrated stronger mediation effects, with proportions reaching up to 13.6%. Participants with concurrent exposure to poor sleep, high genetic risk, and adverse metabolic profiles showed significantly worse cognitive outcomes compared to those without these risk factors, with effect sizes exceeding those in single or dual exposure groups. Plasma metabolic signatures, particularly those involving BCAA metabolism, may serve as biological intermediaries linking poor sleep to worse cognitive function in older adults and could help identify populations at an elevated risk of cognitive impairment. Longitudinal and experimental studies are required to validate these associations and develop metabolic-based strategies for cognitive preservation.
24. Identifying expression and DNA methylation biomarkers for lung adenocarcinoma risk in East Asia.
期刊: Journal of the National Cancer Institute 发表日期: 2026-Jan-24 链接: PubMed
摘要
Lung adenocarcinoma (LUAD) is the most common type of lung cancer. A recent genome-wide association study (GWAS) of LUAD in East Asia reported 28 independent susceptibility variants across 25 loci and identified 2 genes whose genetically predicted expression levels are associated with LUAD risk, using an ancestry-matched lung tissue expression quantitative trait loci (eQTL) dataset. It is desirable to identify additional susceptibility loci and to understand their underlying biological mechanisms. Using an expanded GWAS of LUAD in East Asia and ancestry-matched lung tissue eQTL and DNA methylation QTL datasets, we performed transcriptome-wide association studies and DNA methylome-wide association studies simultaneously and examined the association between measured expression of genes and DNA methylation of nearby CpGs (eQTM). Genes and nearby CpGs are termed CpG-gene-LUAD trios if these three associations hold simultaneously. At Bonferroni-corrected P < .05, we identified a new susceptibility locus (6p21.31; lead SNP rs7772643), 10 LUAD-associated genes and 86 LUAD-associated CpGs. At false discovery rate q < 0.05, we identified 28 LUAD-associated genes, 220 LUAD-associated CpGs, and 45 CpG-gene-LUAD trios; among them, 43 were direction-matched regarding these three associations. These show that 23 of the known 28 susceptibility variants for LUAD in East Asia are near these genes or CpGs and MARCH3, ELF5, IKZF3, GSDMB, CCDC116, and DSP are putative novel susceptibility loci. Few of them was reported in LUAD in European populations. This study substantially advances our understanding of the etiology of LUAD in East Asia and could be useful in developing translational applications.
25. Persistent Racial Disparities in Lung Cancer Survival and the Overlooked Role of Post-Treatment Care.
期刊: QJM : monthly journal of the Association of Physicians 发表日期: 2026-Jan-24 链接: PubMed
摘要
26. Process and Outcome Evaluation of the National Institutes of Health Community Engagement Alliance.
期刊: Public health reports (Washington, D.C. : 1974) 发表日期: 2026-Jan-24 链接: PubMed
摘要
In 2020, the National Institutes of Health (NIH) established the Community Engagement Alliance (CEAL) to ensure that communities experiencing health disparities had a voice in finding effective solutions. This mixed-methods study evaluated processes and outcomes of CEAL. We used the National Academy of Medicine’s Assessing Meaningful Community Engagement conceptual model to guide our evaluation. Data sources for the evaluation included interviews, programmatic data, community surveys, and partner surveys. We assessed the domains of strengthened partnerships, expanded knowledge, and improved health, health programs, and policies. CEAL teams built a robust partnership network that reached populations most affected by COVID-19, facilitated knowledge increases among community members and partner organizations, and positively affected COVID-19 vaccination rates. This evaluation suggests that the infrastructure built by CEAL teams could be leveraged to address additional topics and populations of interest and enhance future National Institutes of Health-funded efforts in community-engaged research.
27. Alzheimer Disease and Related Dementias in the Deaf Community: A Scoping Review.
期刊: Public health reports (Washington, D.C. : 1974) 发表日期: 2026-Jan-24 链接: PubMed
摘要
Despite Alzheimer disease and related dementias/disorders (ADRD) being a substantial public health concern, the Deaf community remains underrepresented in ADRD research. We examined the extent and nature of existing literature on ADRD in the Deaf community. We conducted a scoping review following Arksey and O’Malley’s framework, adhering to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses. We searched 7 databases for peer-reviewed studies published in English, with no restrictions on publication date or study design. Inclusion studies addressed ADRD within the Deaf community and examined aspects such as diagnosis, care, and communication. Our search identified 435 articles, of which 16 met the inclusion criteria. Studies primarily originated from the United Kingdom and Finland, followed by the United States. Most used qualitative methodologies and explored lived experiences and communication barriers. Common themes included limited access to culturally competent care and caregiving challenges. Few studies highlighted diagnostic interventions but noted a general scarcity of resources tailored to Deaf populations. Notable gaps emerged in geographic focus, the range of studied variables, and the lack of validated sign language-based diagnostic instruments and interventions. We recommend expanding research beyond the Global North (ie, higher-income industrialized countries with greater access to resources), incorporating more longitudinal and intersectional approaches, and tailoring resources for Deaf communities. The review underscores the need for culturally competent care, improved diagnostic tools, and policy reforms to address ADRD-related disparities in the Deaf community. Future research should prioritize inclusive methodologies and community-driven interventions to enhance health outcomes and equity for Deaf individuals affected by ADRD.
28. From commitment to action: lessons from 18 transdisciplinary projects addressing health risks in wildlife trade.
期刊: One health outlook 发表日期: 2026-Jan-24 链接: PubMed
摘要
29. Post-acute healthcare expenditure following COVID-19 hospitalization and associated social inequalities in Belgium: a matched cohort study.
期刊: BMC health services research 发表日期: 2026-Jan-24 链接: PubMed
摘要
30. Following the youth patient journey in the mental health help-seeking process in Bogotá, Colombia.
期刊: International journal of mental health systems 发表日期: 2026-Jan-24 链接: PubMed
摘要
Understanding help-seeking behaviors of young people with mental health concerns is crucial for developing responsive mental health services and policies. This study aimed to explore the help-seeking journeys of Colombian youth, the formal and informal services they reached out to when faced with psychological distress and the order in which these services were consulted. Additionally, it examined the differences between pathways of actual service users and those modeled by fictional characters. This study employed a mixed-methods design to explore help-seeking behaviors among Colombian youth (ages 10-19) facing mental health concerns, with a focus on service usage, sequence of access, and differences between actual (Clinical Sample, CLS) and perceived pathways (Community Sample, COS). The methodology combined semi-structured interviews, visual journey mapping, and social network analysis (SNA) to capture both qualitative and quantitative dimensions. 30 young people (53% female, median age = 16, IQR = 3) participated in interviews, of which 19 disclosed past service usage (CLS) and 11 narrated hypothetical scenarios (COS). The findings revealed the absence of a ‘typical’ care seeking pathway. A trend, however, was observed of prioritizing informal services, such as friends and family, as an initial step in help-seeking behavior. CLS participants reported longer and more complex service pathways, averaging 14.7 services, often involving specialists such as psychiatrists and other medical specializations, with third-party involvement (e.g., parents, educators) in initiating contact. Hypothetical journeys were shorter, with a median of 8 services, always initiated by the characters, and mostly resolved within community settings, with educators and psychologists as key sources of support. In both groups, the primary objective of help-seeking was symptom reduction; however, actual service users took two times longer (Mdn = 120, IQR = 700) to seek helpfrom the onset of symptoms than those projected on fictional characters (Mdn = 60 days, IQR = 90). The study demonstrates the importance of informal support systems regardless of youth’s past service usage and help-seeking experience. It also reveals discrepancies between how help-seeking is perceived and experienced showing an underestimation of the complexity involved in finding mental health support which could potentially explain delays in help initiation and difficulties in navigating support resources.
31. Building research capacity in sub-Saharan Africa: findings from a pilot scientific writing workshop in Cameroon.
期刊: BMC research notes 发表日期: 2026-Jan-24 链接: PubMed
摘要
Sub-Saharan Africa produces less than 4% of global scientific output, despite significant health and development challenges. This study evaluated the effectiveness of a pilot scientific writing workshop in Cameroon aimed at building writing skills and publication readiness of early career researchers. We conducted two workshops’ sessions in Yaoundé, Cameroon, in April and November 2023. A mixed-methods approach was used. Quantitative data were obtained via pre- and post-workshop questionnaires designed to capture participants’ self-assessed knowledge, skills, and confidence related to the workshop content. Qualitative data were gathered through in-depth interviews. Descriptive and inferential statistics were applied to the survey data, and thematic content analysis was used to assess qualitative responses. A total of 86 participants completed both the pre- and post-workshop surveys (response rate: 86.9%). The majority had never published scientific papers (62.8%) nor had they received formal writing training (61.6%). The quantitative results showed statistically significant improvements in participants’ overall understanding of scientific writing and publishing (mean difference = 0.93, p < 0.001) and confidence regarding writing skills (mean difference = 0.94, p < 0.001). Thematic analysis of the interviews revealed high satisfaction with the learning environment, perceived knowledge gains, and a strong demand for mentorship and sustained training opportunities.
32. Impact of inpatient volume on residents' In-training examination scores and burnout in Japanese community hospitals: a nationwide cross-sectional study.
期刊: BMC medical education 发表日期: 2026-Jan-24 链接: PubMed
摘要
The optimal hospital size between adequate clinical training and resident well-being remains underexplored, particularly within Japan’s unique medical training environment. This study examined the relationship between residents’ nationwide General Medicine In-Training Examination (GM-ITE®) scores and their mental health to evaluate the validity of inpatient volume as a criterion for training hospital designation. We conducted a nationwide cross-sectional study of 7,498 postgraduate year (PGY)-1 and PGY-2 residents from 608 community-based hospitals in Japan who participated in the GM-ITE® from January 17 to 30, 2024. The GM-ITE® is a highly reliable test for evaluating residents’ basic clinical skills. The 2023 GM-ITE® included 80 multiple-choice questions with a maximum score of 80. In the Mini Z 2.0 survey, a score of 3 or more was defined as the presence of burnout symptoms. Training facilities were categorized into four groups by yearly inpatient volume: Very Low (< 3,000), Low (3,000-5,999), Moderate (6,000-9,999), and High (≥ 10,000). We explored the relationships using multivariable analysis between GM-ITE® score, burnout symptoms, and training environment. The GM-ITE® scores in the Very Low-Volume group were significantly higher than those of the Low-Volume group (45.8 ± 7.3 vs. 44.3 ± 7.1; adjusted coefficient (AC): 2.007; p = 0.021), but did not differ significantly from those of the Moderate- (45.8 ± 7.3 vs. 44.9 ± 6.7; AC: 1.637; p = 0.060) or High-Volume (45.8 ± 7.3 vs. 46.2 ± 6.9; AC: 1.638; p = 0.082) groups. The prevalence of burnout symptoms among residents in the Very Low-Volume group, did not differ significantly from that of residents in the Low- (13.5% vs. 13.1%; adjusted odds ratio (aOR): 0.974; p = 0.940), Moderate- (13.5% vs. 12.8%; aOR: 0.967; p = 0.923), and High-Volume groups (13.5% vs. 12.1%; aOR: 0.994; p = 0.986). Residents at Very Low-Volume hospitals achieve comparable GM-ITE® scores and mental health outcomes to those of residents at larger hospitals. Even Very Low-Volume hospitals are individually assessed, and if recognized as having an educational environment where residents can acquire basic clinical skills, it may be appropriate to certify them as core clinical training hospitals. The educational environment in Very Low-Volume hospitals could be enhanced by supporting residents’ mental health and advancing international clinical training programs.
33. Impacts of COVID-19 mobility-restricting policies and perceived COVID-19 risks on household unmet medical needs in Nigeria: a difference-in-differences analysis.
期刊: BMC health services research 发表日期: 2026-Jan-24 链接: PubMed
摘要
34. Placental transfer of third-generation antiepileptic drugs: in vivo lacosamide case study and in vitro investigation of transporter inhibition by lacosamide and perampanel.
期刊: Journal of pharmaceutical health care and sciences 发表日期: 2026-Jan-24 链接: PubMed
摘要
35. Sex hormone-responsive human vaginal epithelial organoids: a novel in vitro platform for studying Chlamydia trachomatis infection.
期刊: Cell communication and signaling : CCS 发表日期: 2026-Jan-24 链接: PubMed
摘要
36. Troxipide nanosuspensions prevent indomethacin‑induced gastrointestinal lesions in adjuvant-induced arthritis rats.
期刊: Journal of pharmaceutical health care and sciences 发表日期: 2026-Jan-24 链接: PubMed
摘要
37. Association between cerebrospinal fluid volume and frailty in community-dwelling older adults: a cross-sectional study.
期刊: Fluids and barriers of the CNS 发表日期: 2026-Jan-24 链接: PubMed
摘要
Impaired cerebrospinal fluid (CSF) dynamics may affect brain health in older adults and contribute to age-related changes in brain structure. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a neuroimaging finding associated with impaired CSF dynamics. However, the association between frailty-a condition characterised by increased vulnerability in late life-and DESH-related CSF space volumes remains poorly understood. Therefore, in this study, we aimed to investigate this association. This cross-sectional study was conducted using data from 1,395 community-dwelling Japanese adults aged ≥ 65 years without dementia. Frailty was assessed using the Japanese version of the Fried criteria, comprising slowness, weakness, low activity, shrinking, and exhaustion. Volumes of regions of interest (ROIs) were measured by magnetic resonance imaging, and DESH-related regions (ventricular system [VS], Sylvian fissures [SF], and the subarachnoid space at the high convexity and midline [SHM]) were quantified using voxel-based morphometry. Ordinal logistic regression analysis was conducted with frailty status (robust [reference], prefrail, or frail) as the dependent variable and each ROI volume as independent variables. The results showed positive associations of VS volume (odds ratio [OR] 1.21; 95% confidence interval [CI] 1.06-1.37) and SF volume (OR 1.81, 95% CI 1.09-3.02) with frailty, whereas SHM volume was negatively associated (OR 0.84, 95% CI 0.72-0.97). Logistic regression analyses of each frailty component and ROIs showed that slowness (slow gait speed) was consistently associated with all three DESH-related regions (false-discovery rate-adjusted q < 0.05). DESH-related CSF space volumes, reflecting impaired CSF dynamics, were significantly associated with frailty in community-dwelling older adults. These findings highlight the potential role of CSF dynamics as a neural mechanism underlying frailty and suggest a novel target for preventive strategies.
38. Overcoming barriers to vaccination among U.S. farmworkers: a scoping review of targeted interventions and strategies.
期刊: BMC public health 发表日期: 2026-Jan-24 链接: PubMed
摘要
39. A Delphi study to prioritize implementation strategies to increase the adoption of screening and referral for brain injury among survivors of intimate partner violence and sexual assault within community-based organizations.
期刊: BMC public health 发表日期: 2026-Jan-24 链接: PubMed
摘要
40. Transcriptomic insights into cultivation-driven virulence in Aeromonas spp.: a new approach to optimizing autogenous vaccines in aquatic veterinary medicine.
期刊: Veterinary research 发表日期: 2026-Jan-24 链接: PubMed
摘要
Autogenous vaccines are a critical tool in aquaculture for managing bacterial diseases when commercial vaccines are unavailable or ineffective. To improve vaccine efficacy, this study explored how different cultivation conditions influence virulence gene expression in two major fish pathogens, Aeromonas salmonicida subsp. salmonicida and Aeromonas hydrophila. Isolates were cultured in nutrient-rich (tryptic soy broth [TSB]) and nutrient-limited (Mueller-Hinton broth [MH]) media, with and without supplementation of 1% fetal bovine serum (tryptic soy broth supplemented with 1% FBS [TSB1] and Müller-Hinton supplemented with 1% FBS [MH1]), to mimic environmental and host-like conditions. Total RNA was sequenced using the Oxford Nanopore MinION platform, and gene expression was quantified using featureCounts and Salmon, followed by differential expression analysis with DESeq2. Results revealed that culture conditions significantly shaped transcriptomic profiles. TSB1 promoted the highest and most consistent expression of classical virulence genes such as aerA, exeC, and fliP, due to serum-derived host signals. In contrast, MH induced higher expression of genes linked to motility and early host interaction, including flpI and exeB, despite overall lower transcriptional activity. These findings highlight the complementary expression of virulence factors under distinct nutritional conditions. Heatmaps and principal component analysis (PCA) confirmed clustering of expression profiles across media types. In relation to our findings, TSB1 is therefore recommended as the primary medium for bacterin production in autogenous vaccine development. However, combining cultures grown in both TSB1 and MH may capture a broader antigen repertoire, enhancing immune recognition and protection. This transcriptomics-based strategy presents as a rational framework for designing next-generation autogenous vaccines in aquatic veterinary medicine.
41. Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction.
期刊: Toxicological sciences : an official journal of the Society of Toxicology 发表日期: 2026-Jan-24 链接: PubMed
摘要
Chronic kidney disease (CKD) affects ∼15% of U.S. adults and over 840 million people worldwide. Environmental contaminants, including pesticides and metals, are increasingly recognized as disease contributors, yet mechanisms and consequences of long-term, low-level mixture exposures remain poorly defined. Our prior work identified glyphosate and metals (cadmium, arsenic, lead, vanadium) in drinking water from agricultural regions with high CKD prevalence and showed that early-life co-exposures disrupt kidney development. Here, using adult zebrafish as a mechanistic model, we tested whether chronic, low-level exposure to glyphosate, metals, and their combination impairs kidney function and structure. We exposed zebrafish for 10 and 60 days to glyphosate (10 ppb), metals (2 ppb Cd, 4 ppb As, 5 ppb Pb, 15 V), or glyphosate + metals and evaluated low-molecular weight proteinuria, histopathology, metabolomics, mitochondrial function, mitochondrial copy number, and mitophagy in the kidney. Chronic exposure to glyphosate and metals produced distinct yet overlapping kidney toxicity signatures, including tubular injury, altered metabolism, and impaired mitochondrial function. Co-exposures generated the most severe effects, with mitochondrial beta oxidation, respiration, and mitophagy as sensitive targets. These findings demonstrate that glyphosate and metals at levels found in drinking water damage kidney function over time, with co-exposure worsening outcomes compared to individual chemicals. Our study identifies mitochondria-rich proximal tubules as critical targets of chronic glyphosate-metal exposure, providing mechanistic insight into how environmental contaminants contribute to CKD risk. This work advances understanding of disease etiology in environmental nephropathies and highlights environmental factors as important drivers of kidney health.
42. Maternal exposure to air pollution alters the postnatal metabolic response to ozone in peri-adolescent offspring.
期刊: Toxicological sciences : an official journal of the Society of Toxicology 发表日期: 2026-Jan-24 链接: PubMed
摘要
Exposure to environmental pollutants during key stages of development increases the risk of disease later in life. One such toxicant with growing evidence of this response is the air pollutant, ozone (O3). Exposure to O3 during the implantation receptivity period in rats affects the metabolic status of offspring at adolescence, which may increase their susceptibility to subsequent environmental exposures. Herein, we studied the impacts of maternal O3 exposure on postnatal systemic responses to O3 in male and female offspring. Following peri-implantation O3 exposure (0.8 ppm for 4 hours/day on gestation days 5 and 6), offspring were exposed to O3 for 1 day/week on postnatal weeks 5-7. After the final exposure, metabolic effects were analyzed by circulating hormones and clinical chemistries, as well as hepatic lipid status and transcriptomic alterations. By and large, male offspring from O3-exposed dams were more greatly impacted than those from air-exposed dams. This included increased hepatic lipid mobilization, increased circulating glucose, and a robust number of differentially expressed genes (2,348). Interestingly, many of these transcriptomic differences were attributed to maternal O3 exposure, with 1,741 of these genes sharing directional similarity with postnatally exposed air littermates. Females, on the other hand, reported minimal baseline effects of maternal O3 exposure (108). However, postnatal O3 exposure in female offspring substantially increased these differences to 947 genes. Collectively, this work supports the growing evidence that early pregnancy exposure to O3 alters the metabolic development of the offspring. Furthermore, postnatal exposure to environmental stressors reveals hepatic susceptibilities that are sexually dimorphic.
43. When did we start calling it silicosis? A historical perspective on the naming of an occupational disease.
期刊: Journal of occupational medicine and toxicology (London, England) 发表日期: 2026-Jan-24 链接: PubMed
摘要
44. TeMPRA: advancing continuing professional development in pediatric rheumatology in Japan.
期刊: Pediatric rheumatology online journal 发表日期: 2026-Jan-24 链接: PubMed
摘要
45. Research on the current status and influencing factors of knowledge, attitude and practice of occupational therapy among ICU healthcare professionals in Jiangsu Province: a cross-sectional study.
期刊: BMC health services research 发表日期: 2026-Jan-24 链接: PubMed
摘要
To understand the current status of knowledge, attitude and practice (KAP) of occupational therapy (OT) among healthcare professionals in intensive care unit (ICU) and analyze the influencing factors, to provide reference for nursing managers in developing targeted measures to promote the adoption of OT. From January to March 2025, we conducted a cross-sectional survey using convenience sampling among 511 ICU healthcare professionals across 13 cities in Jiangsu Province. Participants completed anonymous online questionnaires, including a general information form and a validated, self-developed Knowledge, Attitudes, and Practices (KAP) questionnaire to OT for ICU healthcare professionals. The KAP instrument comprised three dimensions: knowledge (12 items), attitude (16 items), and practice (14 items). We performed univariate analysis and multivariable logistic regression using SPSS 25.0 to identify associated factors. A total of 464 valid questionnaires was received (90.8% response rate). The overall KAP performance showed an average score of 156.58 ± 31.16. Attitudes achieved the highest average score (67.54 ± 10.99), while knowledge showed the lowest (37.88 ± 13.56). Knowledge correlated positively with attitude and practice. Multivariate logistic regression identified age, professional title, ICU experience, hospital level, and OT-related knowledge training as factors influencing ICU healthcare professionals ‘ KAP levels. This KAP survey provides a diagnostic foundation for OT implementation, it indicates that educational training is a necessary, high-impact strategy. However, the negative association with seniority and hospital level indicates that a simple educational strategy may be insufficient; tailored strategies addressing organizational culture, workload, and professional role expectations in those specific contexts will be required. Not applicable (This study did not require registration in a clinical trials registry because it is an observational cross-sectional study).
46. How does premenstrual syndrome affect occupational performance?
期刊: BMC women’s health 发表日期: 2026-Jan-24 链接: PubMed
摘要
47. Investigation of airborne microplastics emission and characteristics in hospital laundry environments.
期刊: Scientific reports 发表日期: 2026-Jan-24 链接: PubMed
摘要
Plastic pollution has emerged as a critical global concern, with microplastics increasingly detected across various ecosystems, including the atmosphere. Among indoor sources, hospital laundry units have been identified as significant contributors to airborne microplastic emissions. This study investigates the concentration of inhalable microplastics (MPs (in the air of a hospital laundry environment. In this study, air sampling was conducted at three different time points using a personal air sampler operating at a flow rate of 0.5 L/min for 40 min per sample. Microplastics were characterized using FTIR, SEM, and EDX to ensure accurate identification. FTIR analysis identified the predominant polymer as polyamide (nylon), with characteristic peaks consistent with CH2, C = O, and N-H groups. EDX analysis indicated an elemental composition of C (59%), N (32%), O (7%), and P (0.07%). SEM images revealed pronounced diurnal and day-to-day variability, with particle concentrations ranging from 43575 to 66975 particles/m3, though statistical analysis showed these variations were not significantly influenced by environmental factors such as humidity and air velocity in this short-term study. Notably, black particles dominated the samples, representing 97% of the MPs. These results underscore the potential for direct inhalation exposure in occupational settings, raising concerns about respiratory health risks for laundry staff and patients. Therefore, further research is needed to inform the development of stricter ventilation standards, occupational safety measures, and regulatory policies to mitigate microplastic emissions in healthcare environments.
48. C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen.
期刊: Cell reports 发表日期: 2026-Jan-23 链接: PubMed
摘要
Gut dysbiosis and neural inflammation occur in patients with amyotrophic lateral sclerosis (ALS), including those with a causal mutation in chromosome 9 open reading frame 72 (C9ORF72). How gut commensals interact with common ALS genotypes to impart risk of neural degeneration remains unclear. Here, we identify 10 phylogenetically diverse bacterial strains that promote cytokine release in a C9orf72-dependent manner. Metatranscriptomics implicated the glycogen biosynthesis pathway as a driver of inflammation. Colonization of germ-free C9orf72-deficient mice with Parabacteroides merdae that produced inflammatory glycogen enhanced monocytosis, blood-brain barrier breakdown, and T cell infiltration into the central nervous system. Enzymatic digestion of glycogen in the gut promoted survival of C9orf72-deficient mice and dampened microglial reactivity in the brain. A survey of human fecal samples demonstrated that inflammatory forms of glycogen were present in gut contents from 15/22 patients with ALS, 1/1 patient with C9ORF72 frontotemporal dementia (FTD), and 4/12 healthy controls. Together, the results of this work identify bacterial glycogen as a modifiable mediator of immune homeostasis in the gut and brain.
49. Diagnostic Accuracy of Non-Invasive Fatty Liver Indexes and Their Association with ECORE-BF scale in a Cohort of 386,924 Spanish Workers.
期刊: Gastroenterologia y hepatologia 发表日期: 2026-Jan-22 链接: PubMed
摘要
To evaluate the diagnostic accuracy of five non-invasive fatty liver indices and their association with obesity in a large cohort of Spanish workers, stratified by sex. A cross-sectional analysis was conducted on 386,924 workers (232,814 men and 154,110 women) who underwent routine occupational health assessments between 2009 and 2019. Anthropometric, clinical, and biochemical parameters were collected following standardized procedures. Physical activity and adherence to the Mediterranean diet were assessed using validated IPAQ and PREDIMED questionnaires. Diagnostic performance was evaluated using ROC curves and area under the curve (AUC) values for each fatty liver index. All indices showed significant sex-based differences. FLI and LAP presented the highest AUC values for identifying obesity in both sexes (FLI: AUC 0.907 in men and 0.972 in women; LAP: AUC 0.836 in men and 0.878 in women). FLI also demonstrated the strongest association with higher obesity prevalence across tertiles. ZJU showed good performance, whereas HSI and FLD exhibited lower accuracy, particularly among men. Lifestyle factors and education level influenced index values, with sedentary behavior, low adherence to the Mediterranean diet, and lower educational attainment associated with worse index performance. FLI and LAP are the most accurate non-invasive indices for identifying obesity-associated fatty liver in this large Spanish working population. Their performance varies by sex and is influenced by sociodemographic and lifestyle factors. These findings support the relevance of FLI and LAP for large-scale screening and highlight the importance of integrating lifestyle assessments into occupational health evaluations.
50. Update to RIFM fragrance ingredient safety assessment, naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)-, CAS Registry Number 6790-58-5.
期刊: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 发表日期: 2026-Jan-22 链接: PubMed
摘要
Naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- is not genotoxic, provide a calculated Margin of Exposure (MOE) >100 for the repeated dose toxicity and reproductive toxicity endpoints, and show that there are no safety concerns for naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on data and ultraviolet/visible (UV/Vis) spectra; naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- is not photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- is below the TTC (0.47 mg/day). The environmental endpoints were evaluated; naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
51. Demography and outcomes of frozen tongue: a scoping review of Scandinavian tundra tongue cases.
期刊: International journal of pediatric otorhinolaryngology 发表日期: 2026-Jan-20 链接: PubMed
摘要
Children occasionally adhere their tongues to cold metal surfaces during winter (“tundra tongue”), but little is known about the epidemiology and outcomes of these cases. To explore the following questions: who experiences tundra tongue, under which circumstances does it occur, and what are the outcomes? We conducted a scoping review to identify case reports published in historical newspapers from Norway, Sweden and Denmark using national library databases. Epidemiological data were charted manually from newspaper items describing literal frozen tongues. Among 17,009 unique search hits, 856 reports of 113 different cases were identified. Almost all cases (96 %) involved children, median age 5.25 years, and the majority were boys (63 %). Tongues were most often frozen to railings (40 %). Ambient temperature was reported in 18 cases with a median of -16.5 °C. Outcomes ranged from discomfort to potential amputation of tongue tissue, with 20 (18 %) cases involving a doctor or a hospital. Severe injuries were reported in several cases through three distinct mechanisms: (1) the direct effect of cold on tissue, (2) detachment injuries, and (3) the consequences of immobility. Children, and especially boys, in wintertime, are vulnerable to tundra tongue. Most cases had no or mild consequences but severe injuries were also described in multiple cases. Hence, parents, health care professionals and policymakers should not underestimate the potential harm of tundra tongue.
52. Levels of and changes in psychosis symptoms and clinical insight: Exploring the impact of differential antipsychotic mechanisms.
期刊: Psychiatry research 发表日期: 2026-Jan-09 链接: PubMed
摘要
Impaired clinical insight is common in schizophrenia spectrum disorders (SSDs) and predicts poor treatment adherence and outcomes. It is linked to disorganised, positive, negative, and hostility symptoms. However, few studies repeatedly assess insight after antipsychotic initiation while comparing pharmacologically distinct agents. This study examined how symptom levels and changes predict the development and endpoint of clinical insight over 6 weeks, contrasting the partial dopamine agonist aripiprazole (PDA) with two dopamine antagonists (DAs). Data from 144 SSD patients in the Bergen-Stavanger-Innsbruck-Trondheim (BeSt InTro) trial, a pragmatic, semi-randomised study of amisulpride, aripiprazole, and olanzapine, were analysed using latent growth curve models. Insight was measured by PANSS Item G12; symptom factors (positive, negative, hostility, cognitive/disorganised) were derived from PANSS. Lower baseline symptoms and greater improvement between weeks 3 and 6 predicted better insight at 6 weeks across all factors. For positive symptoms, improvement between weeks 1 and 3 (b = 0.57, p = 0.009) also predicted better insight. Patients on aripiprazole showed less improvement in insight, though some findings lost significance after correction. Symptom reduction is associated with improved insight, with early changes in positive symptoms exerting the fastest effect. Despite symptom improvement, aripiprazole PDA treatment was linked to less insight gain than DA treatment. These preliminary findings warrant further study.
53. Association of immune-related adverse events with survival outcomes in esophageal squamous cell carcinoma following neoadjuvant chemoimmunotherapy: a national multicenter retrospective cohort study in China.
期刊: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 发表日期: 2026-Jan-09 链接: PubMed
摘要
Although immune-related adverse events (irAEs) are increasingly recognized as biomarkers of response to immunotherapy in advanced cancers, their prognostic role in the neoadjuvant setting for esophageal squamous cell carcinoma (ESCC) remains unclear. This retrospective multicenter cohort study aimed to evaluate the associations between irAEs, pathological response, and 2-year survival outcomes in patients with locally advanced ESCC treated with neoadjuvant chemoimmunotherapy (NCIT) followed by esophagectomy. A total of 1076 patients with cT1bN1-3 M0 or cT2-4aN0-3 M0 ESCC who received NCIT and surgery between January 2019 and March 2023 across 26 tertiary centers in China were included. IrAEs, defined according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0, were observed in 181 patients (16.8%), with rash/pruritus being the most common. Patients who developed irAEs completed fewer NCIT cycles and had longer treatment-to-surgery intervals, both of which were independently associated with worse disease-free survival (DFS). Although the occurrence of irAEs correlated with inferior overall survival (OS)-particularly pneumonitis and rash/pruritus-multivariable analysis revealed that irAEs were not independent predictors of either OS or DFS. The strongest independent predictors of survival were pathological nodal status (ypN3) and poor tumor regression (TRG4). In conclusion, despite being linked to prolonged treatment-to-surgery intervals, irAEs were not significantly associated with pathological response or long-term survival outcomes in this cohort of ESCC patients treated with NCIT and surgery, underscoring the importance of effective management of irAEs during neoadjuvant therapy.
54. Machine learning for enzyme catalytic activity: current progress and future horizons.
期刊: Briefings in bioinformatics 发表日期: 2026-Jan-07 链接: PubMed
摘要
Enzyme catalysis, with its advantages in environmental sustainability and efficiency, is gaining traction across diverse industrial applications, such as waste utilization and pharmaceutical biomanufacturing. However, optimizing enzyme catalytic activity remains a significant challenge. To facilitate enzyme mining and engineering, machine learning (ML) models have emerged to predict enzyme substrate specificity, enzyme turnover number, and enzyme catalytic optimum. This review endeavored to assist researchers in effectively utilizing predictive models for enzyme catalytic activity through presenting recent advancements and analyzing different approaches. We also pointed out existing limitations (e.g. dataset imbalance) and offered suggestions on potential enhancements to address them. We identified that the attention mechanism, inclusion of new features such as product information and temperature, and using transfer learning to leverage different datasets were three main useful modeling strategies. Furthermore, we envisaged that accurate predictors of enzyme catalytic activity would potentially transform enzyme and metabolic engineering, and the optimization of biocatalysis.
55. Spatio-temporal trends in pleural mesothelioma mortality in Italy: a 40-year analysis by calendar period and birth cohort.
期刊: International journal of epidemiology 发表日期: 2026-Jan-02 链接: PubMed
摘要
Italy, among the leading asbestos producers and users until the national ban in 1992, continues to register a high burden of asbestos-related diseases, mainly due to their long latency and delays in remediation. This study investigates the spatio-temporal evolution of pleural mesothelioma (PM) mortality over the past 40 years. Malignant pleural tumours and PM deaths (1980-2020) were extracted from the national death registry, adjusted for misclassification of pleural tumours, and analysed by region and birth cohort (1905-1984). The analyses by calendar period and cohort, stratified by sex assigned at birth, were followed by a space-cohort Bayesian Hierarchical Model with structured random effects for time (cohorts up to 1960-1969) and space (administrative regions). In Italy, from 1980 to 2020, 35 134 people died from PM (24 380 males and 10 754 females). A mortality decrease was observed in males after 2010-14 and in females after 2000-4. Mortality steadily declined in both males and females across cohorts after 1935-44. The space-time analysis enabled the clear identification of the Italian regions most affected by PM. Italy’s trend mirrors those of other Western countries that have banned asbestos, with the highest risks for birth cohorts in working age before the ban. The results reveal distinct spatio-temporal patterns, with the northern regions exhibiting the highest rates. The Italian experience with asbestos-related diseases detection could help other countries to assess the impact of asbestos, raise awareness, and promote a global ban on asbestos.
56. Meta-Analysis of Treatment Methods for Poststroke Cognitive Impairment: A Network Analysis of Various Interventions.
期刊: Brain and behavior 发表日期: 2026-Jan 链接: PubMed
摘要
Poststroke cognitive impairment (PSCI) is a common neurological consequence of stroke that significantly impacts patients’ quality of life and functional recovery. This meta-analysis aimed to evaluate and compare the efficacy of various treatment modalities for PSCI. We conducted a systematic search of multiple databases and identified eligible randomized controlled trials (RCTs) investigating treatments for PSCI. Eleven RCTs with 904 participants evaluating seven different interventions were included in the network meta-analysis. The treatments included transcranial direct current stimulation (tDCS), acupuncture, Baduanjin exercise, transcranial ultrasound stimulation (TUS), moderate-intensity aerobic exercise, modified Suanzaoren decoction, and cognitive training alone (control). Network meta-analysis showed that all interventions demonstrated some degree of efficacy compared to cognitive training alone, with Baduanjin exercise and tDCS ranking highest for improving cognitive function. Publication bias assessment showed no significant bias. This comprehensive analysis suggests that non-pharmacological interventions, particularly neuromodulation techniques and traditional Chinese exercise, may offer promising approaches for PSCI treatment. These findings provide evidence-based guidance for clinical decision-making, though more large-scale, high-quality RCTs are needed to strengthen these conclusions.
57. Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization.
期刊: Brain and behavior 发表日期: 2026-Jan 链接: PubMed
摘要
Given inconsistent evidence regarding the migraine-Alzheimer’s disease association, this Mendelian randomization (MR) study examines their potential causal relationship. GWAS summary statistics for migraine and Alzheimer’s disease were acquired from the IEU Open GWAS repository. We implemented a multi-stage MR framework comprising (1) univariate analysis, (2) independent replication, (3) multivariable MR, (4) meta-analysis to evaluate migraine-AD causality. Univariate results showed OR = 13.43, 95% CI: 2.86-63.16, P < 0.01; replication Mendelian randomization results were OR = 12.64, 2.89-55.38, P < 0.01 with OR = 1.13, 95% CI: 1.06-1.21, P < 0.01, meta-analysis results were OR = 1.14, 95% CI: 1.07- 1.22, P < 0.01. Multivariate Mendelian randomization results were OR = 18.90, 95% CI: 1.69-210.88, P < 0.01. Considering the observed epidemiological correlations and shared pathophysiological mechanisms between migraine and Alzheimer’s disease (AD), we propose that chronic migraine may increase the susceptibility to AD through complex biological interactions. This hypothesis is reinforced by our Mendelian randomization (MR) findings, which support a causal relationship. Therefore, early and effective intervention in migraine management could serve as a promising strategy to mitigate the future risk of AD onset.
58. Preoperative triglyceride-glucose index as a metabolic predictor of surgical site infection after posterior lumbar fusion.
期刊: Journal of orthopaedic surgery (Hong Kong) 发表日期: 2026 链接: PubMed
摘要
PurposeTo assess whether the preoperative triglyceride-glucose (TyG) index is associated with 30-day surgical site infection (SSI) after instrumented posterior lumbar fusion (PLF) and to examine its predictive performance.MethodsWe retrospectively reviewed consecutive adults who underwent elective one- or two-level instrumented PLF between 2017 and 2024 at a tertiary center. Patients with active infection, revision surgery, tumor, trauma, or incomplete 30-day follow-up were excluded. Preoperative fasting triglycerides and glucose were used to calculate the TyG index as ln[(triglycerides × glucose)/2]. The primary outcome was 30-day SSI defined by Centers for Disease Control and Prevention criteria. Multivariable logistic regression evaluated the association between TyG and SSI, and receiver operating characteristic analysis assessed discrimination and identified an optimal cut-off. Incremental predictive value was examined by comparing a clinical model with and without TyG using AUC, likelihood ratio testing, reclassification metrics, calibration, Brier score, and decision curve analysis with bootstrap internal validation.ResultsAmong 438 patients, 29 (6.6%) developed SSI (24 superficial, 2 deep, 3 organ/space). Patients with SSI had higher TyG values than non-SSI patients (9.1 ± 0.5 vs 8.6 ± 0.6; p < 0.001). Each 1-unit increase in TyG was independently associated with higher odds of SSI (adjusted odds ratio 3.65; 95% confidence interval 1.62-8.24; p = 0.002). TyG alone yielded an area under the curve of 0.73, and a cut-off of 8.80 identified a high-risk group with an SSI rate of 11.8% versus 2.5% in the low-TyG group. Beyond standard clinical factors, adding TyG improved model fit (LRT χ2 = 10.98; p = 0.001) and improved reclassification.ConclusionA higher preoperative TyG index is independently associated with 30-day SSI after PLF and provides moderate discriminative ability as a simple predictor. Incorporating TyG into preoperative risk assessment may help refine perioperative optimization and infection surveillance strategies in lumbar fusion surgery.
59. How culture shapes subjective cognitive decline reporting: Refining assessment tools with digital solutions.
期刊: Alzheimer’s & dementia : the journal of the Alzheimer’s Association 发表日期: 2026-Jan 链接: PubMed
摘要
60. Impact of Mindfulness Meditation on Perceived Stress, Somatic Symptoms and Inflammatory Biomarkers Among Clinical Nurses.
期刊: Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing 发表日期: 2026-Jan 链接: PubMed
摘要
Clinical nurses face notable chronic stress due to work-related stressors, exacerbated by the COVID-19 pandemic, leading to somatic symptoms and low-grade inflammation. Mindfulness meditation has shown promise in reducing stress and improving health outcomes, but its effects on somatic symptoms and inflammatory biomarkers in nurses remain underexplored. To assess the impact of mindfulness meditation on somatic symptoms and inflammatory biomarkers such as leptin, interleukin-6, and tumor necrosis factor-α among nurses. To explore the secondary effects on perceived stress and trait mindfulness because of the complex interlinked association with the primary outcomes of interest. A randomized controlled trial was conducted with 102 nurses randomly assigned to a meditation group (8-week mindfulness meditation program) or a non-meditation group. Data were collected using self-report questionnaires (Mindfulness Attention Awareness Scale, Perceived Stress Scale, Patient Health Questionnaire-15) and blood samples for biomarker analysis at baseline and post-intervention. The meditation group demonstrated notable reductions in perceived stress (p < 0.001), somatic symptoms (p < 0.001), IL-6 (p < 0.001), and leptin levels (p < 0.001) compared to the non-meditation group. Trait mindfulness increased markedly in the meditation group (p = 0.003), while TNF-α levels did not show notable changes. Mindfulness meditation efficiently reduces perceived stress, somatic symptoms, and inflammatory biomarkers in nurses, highlighting its potential as a holistic intervention to improve both psychological and physical well-being in high-stress healthcare environments. ClinicalTrail.gove, NCT06635278.
61. Overreliance on student satisfaction surveys in medical education: a call for reform in evaluation and accreditation practices.
期刊: Academic medicine : journal of the Association of American Medical Colleges 发表日期: 2025-Dec-03 链接: PubMed
摘要
Student satisfaction surveys have become a cornerstone of medical education, influencing critical decisions such as faculty promotion and institutional accreditation. However, the systemic overreliance on satisfaction surveys, especially student evaluations of teaching, is concerning. These self-report surveys, initially designed for formative feedback, are now used to make high-stakes decisions despite their well-documented biases and weak correlations with actual learning outcomes. This overreliance not only diminishes their usefulness but also risks fostering a culture where feedback is devalued, data are underused, and educational quality is potentially compromised. Moreover, the inherent biases in student evaluations of teaching-driven by irrelevant factors such as teacher demographics and other contextual factors-undermine their validity, disproportionately affecting marginalized groups and perpetuating systemic inequities. The overreliance on student satisfaction data in faculty promotion and medical school accreditation further exacerbates these issues, encouraging superficial strategies to boost satisfaction scores rather than substantive improvements in teaching, learning, and assessment. In this Scholarly Perspective, the authors argue for a critical rethinking of the role of student satisfaction surveys in medical education. They encourage the medical education community to reduce reliance on these instruments in favor of more holistic evaluation processes that better reflect educational quality. Although the authors recognize the value of student feedback, they argue it should be integrated within a broader, more evidence-informed evaluation system to provide more meaningful insights. Given the high stakes, the authors advocate for timely, meaningful reform in how the medical education community evaluates educational quality and accredits MD programs in the United States.